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Studying intramolecular bivalent glues using TR-FRET binding assays
Intramolecular bivalent glues can be used for the targeted degradation of proteins. Find out how their binding behaviour can be investigated using microplate readers.
VANTAstar
灵活简化工作流程的读板仪
VANTAstar是我们BMG多功能酶标仪系列的最新成员。这款紧凑型多功能读板仪使用起来更简单，也更具灵活性，检测设置十分轻松，也简化了数据生成。配备我们的专利双LVF光栅系统、滤光片、紫外/可见光谱仪和动态范围扩展技术，可在基础研究和生命科学中广泛应用。
VANTAstar
VANTAstar是一款可升级的多功能读板仪，兼容多达384孔的所有微孔板格式。动态范围扩展技术（EDR）、快速全板自动对焦和减少发光干扰，使分析检测比以往任何时候都更容易，更无需手动优化。
VANTAstar的大气控制单元可用于气体控制、温度培养、多种振荡模式、孔板扫描和试剂注射器以及加热器和搅拌器，可支持所有基于活细胞的分析。VANTAstar也提供只基于滤光片的检测系統。点击此处查看有关VANTAstar F的更多详细信息。
VANTAstar 现配备 Voyager，这是 BMG LABTECH 的全新微孔板读数仪控制界面。Voyager 旨在降低复杂性，同时最大限度地提高灵活性，使数据采集比以往更加直观。
特点
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LVF光栅的波长灵活性和效能
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用EDR自动调整灵敏度
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快速全板自动对焦
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自动减少孔间干扰，优化发光检测
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吸光度、荧光和发光的光谱扫描
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基于活细胞分析的专用功能
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自动开关控制顶部/底部检测功能
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占地面积小
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易于整合到自动化系统中
VANTAstar
酶标仪技术
Studying the molecular basis of antibiotic resistance by assessing penicillin interaction with PBP5 using fluorescence polarization
Antibiotic resistance continues to increase. Find out here how BOCILLIN can be used to study resistant penicillin binding protein variants using fluorescence polarization.
Screening for novel antibiotics in venom against Staphylococcus aureus
The threat of growing antibiotic resistance is constantly increasing. Find out here how venom fractions are emerging as a beacon of hope in the search for novel antibiotics.
dTAG protein degradation assay for the targeted degradation of proteins of interest
Have you heard of dTAG degraders yet? Check out this novel approach in targeted protein degradation and learn how it can be used to identify disease-relevant proteins.
The InToxSA assay, for quantifying Intracellular Cytotoxic S. aureus Phenotypes
Looking for a method to study intracellular bacterial cytotoxicity? This AppNote presents a novel method based on the monitoring of propidium iodide uptake with the CLARIOstar Plus.
Wastewater testing using the biotoxic effect on the luminescent bacterium Aliivibrio fischeri
Are you looking for a device to measure sample`s biotoxicity with Aliivibrio fischeri? BMG LABTECH's luminometers fulfil this task and offer additional advantages over the classic cuvette-based analysis.
Detection Modes
Fluorescence intensity (incl. FRET)
Fluorescence polarization
Luminescence (flash and glow) - incl. BRET
Time-resolved fluorescence
TR-FRET
UV/vis absorbance spectra
Measurement Modes
Top and bottom reading
Endpoint and kinetic
Sequential multi-excitation
Sequential multi-emission
Spectral scanning (fluorescence, luminescence, absorbance)
Ratiometric measurements
Well scanning
Microplate Formats
6- to 384-well plates, user-definable
LVis Plate with 16 low volume microspots (2 μL)
Microplate Carrier
Robot compatible
Light Sources
High energy xenon flash lamp
Detectors
Low-noise photomultiplier tube
CCD spectrometer
Wavelength Selection
Dual Linear Variable Filter (LVF) Monochromators™
Linear Variable Dichroic Mirror
Separates ex & em LVF Monochromators
Optical filters:
Ex and em slides hold up to 5 filters each
LVF Monochromators + optical filters
Use one for ex and the other for em
UV/Vis absorbance spectrometer: Full spectra or 8 distinct wavelengths in < 1 sec/well
Spectral Range
Filters
FI, LUM, TRF, FP, TR-FRET: 240 - 740 nm
LVF Monochromators™
FI, LUM: 320 - 740 nm
Linear Variable Dichroic
340 - 740 nm
Spectrometer
ABS: 220 - 1000 nm; wavelength precision: ≤ 0.5 nm
Sensitivity
FI filters
(top)
< 0.5 pM (< 10 amol/well FITC, 384sv, 20 μL).
FI filters
(bottom)
< 2.5 pM (< 125 amol/well FITC, 384g, 50 μL).
FI monochromator
(top)
< 0.8 pM (< 16 amol/well FITC, 384sv, 20 μL).
FI monochromator
(bottom)
< 3.5 pM (< 175 amol/well FITC, 384g, 50 μL).
Dynamic Range: 8 decades in a single measurement.
FP
< 1.2 mP SD at 1 nM FITC (384sv, 20 μL).
HTRF®
(black and white microplates)
Reader Control Kit (Eu) after 18h (384sv, 20 μL).
Delta F > 700% (High Calibrator).
Delta F > 25% (Low Calibrator).
TRF
< 30 fM europium (< 2.4 amol/well, 384, 80 μL).
LUM
< 0.8 pM (< 15 amol/well ATP, 384sv, 20 μL).
Dynamic range: 8 decades in a single measurement.
ABS with spectrometer
Selectable spectral resolution: 1, 2, 5, and 10 nm.
OD range: 0 to 4 OD; photometric resolution: 0.001 OD.
Accuracy: < 1% at 2 OD.
Precision: < 0.5% at 1 OD and < 0.8% at 2 OD.
Linearity: ≤ 0.8% at 2.0 OD.
Read Times
Flying mode (1 flash)
9 sec (96), 16 sec (384)
Shaking
Linear, circular and double-circular with user-definable time and speed
Incubation
+4 °C above ambient up to 45 °C or 60 °C
Minimum condensation concept: the upper heating plate of the incubation chamber operates at +0.5 °C than the lower plate, heated optic system
Software
Multi-user reader control (SMART Control and Voyager) and data analysis software (MARS).
FDA 21 CFR Part 11 compliance available with SMART Control and MARS.
Integrated fluorophore library.
Dimensions
Width: 35 cm, depth: 52 cm, height: 36 cm; weight: 27 kg
Optical Filters
Excitation and emission slides for up to 4 filters each for monochoromator units (VANTAstar), and for up to 5 filters each for filter-only units (VANTAstar F)
Optical Path Guides
Top and bottom: free-air optical light path guided by motor-driven mirrors and dichroics
Z-Adjustment
Automatic focal height adjustment (0.1 mm resolution)
Reagent Injection
Up to 2 reagent injectors
Individual injection volumes for each well: 3 to 500 μL (optionally up to 1 mL)
Variable injection speed up to 420 μL/s
Reagent back flushing
Heater and stirrer plate
Dimensions: width: 13 cm, depth: 31 cm, height: 26 cm; weight: 6 kg
Power Requirements
- External power supply
- Input Voltage: 100 - 240 V AC, 50 - 60 Hz, auto ranging.
- Input current ≤ 2.0 A.
- Output Voltage: 24 V DC / 6.25 A
Power Consumption
- Standby ≤ 0.15 W
- Idle mode 10 W
- Normal operating conditions 30 W
- Maximum 150 W
Optional Accessories
LVis Plate
Sample capacity: sixteen separate microdrop wells for 2 µL samples; one standard cuvette position for up to 1 mL samples
Quality Control Internal Standards (optional): four NIST traceable optical density filters (approximate values of 0.1, 0.3, 0.6 and 1.0 OD); one holmium oxide filter for wavelength accuracy
Dimensions: conforms to SBS standards for microplates
THERMOstar
Microplate incubator and shaker
Atmospheric Control Unit (ACU)
Actively regulates O2 and CO2 - 1-20%
Optical Filters
Excitation and emission filters
Upgrades
Upgrades to include options such as additional detection modes, reagent injectors, extended temperature control, etc. are available
Please contact your local representative for more information
*
LOD = 3 x SD (20 blanks) / slope (6 pt std curve)
96 = 96-well microplates
384sv = 384-well small volume microplates
384g = 384-well glass bottom microplates
添加更多功能：配件 VANTAstar
THERMOstar
Intelligent microplate incubation
LVis Plate
Low-volume measurements
Filters
Filters for a wide range of applications
Evaluation Plate
Functional Microplate Reader Validation
Atmospheric Control Unit
Enhanced cell-based assays
Compare two readers
Detection Modes
Fluorescence intensity (incl. FRET)
Fluorescence polarization
Luminescence (flash and glow) - incl. BRET
Time-resolved fluorescence
TR-FRET
UV/vis absorbance spectra
Measurement Modes
Top and bottom reading
Endpoint and kinetic
Sequential multi-excitation
Sequential multi-emission
Spectral scanning (fluorescence, luminescence, absorbance)
Ratiometric measurements
Well scanning
Microplate Formats
6- to 384-well plates, user-definable
LVis Plate with 16 low volume microspots (2 μL)
Microplate Carrier
Robot compatible
Light Sources
High energy xenon flash lamp
Detectors
Low-noise photomultiplier tube
CCD spectrometer
Wavelength Selection
Dual Linear Variable Filter (LVF) Monochromators™
Linear Variable Dichroic Mirror
Separates ex & em LVF Monochromators
Optical filters:
Ex and em slides hold up to 5 filters each
LVF Monochromators + optical filters
Use one for ex and the other for em
UV/Vis absorbance spectrometer: Full spectra or 8 distinct wavelengths in < 1 sec/well
Spectral Range
Filters
FI, LUM, TRF, FP, TR-FRET: 240 - 740 nm
LVF Monochromators™
FI, LUM: 320 - 740 nm
Linear Variable Dichroic
340 - 740 nm
Spectrometer
ABS: 220 - 1000 nm; wavelength precision: ≤ 0.5 nm
Sensitivity
FI filters
(top)
< 0.5 pM (< 10 amol/well FITC, 384sv, 20 μL).
FI filters
(bottom)
< 2.5 pM (< 125 amol/well FITC, 384g, 50 μL).
FI monochromator
(top)
< 0.8 pM (< 16 amol/well FITC, 384sv, 20 μL).
FI monochromator
(bottom)
< 3.5 pM (< 175 amol/well FITC, 384g, 50 μL).
Dynamic Range: 8 decades in a single measurement.
FP
< 1.2 mP SD at 1 nM FITC (384sv, 20 μL).
HTRF®
(black and white microplates)
Reader Control Kit (Eu) after 18h (384sv, 20 μL).
Delta F > 700% (High Calibrator).
Delta F > 25% (Low Calibrator).
TRF
< 30 fM europium (< 2.4 amol/well, 384, 80 μL).
LUM
< 0.8 pM (< 15 amol/well ATP, 384sv, 20 μL).
Dynamic range: 8 decades in a single measurement.
ABS with spectrometer
Selectable spectral resolution: 1, 2, 5, and 10 nm.
OD range: 0 to 4 OD; photometric resolution: 0.001 OD.
Accuracy: < 1% at 2 OD.
Precision: < 0.5% at 1 OD and < 0.8% at 2 OD.
Linearity: ≤ 0.8% at 2.0 OD.
Read Times
Flying mode (1 flash)
9 sec (96), 16 sec (384)
Shaking
Linear, circular and double-circular with user-definable time and speed
Incubation
+4 °C above ambient up to 45 °C or 60 °C
Minimum condensation concept: the upper heating plate of the incubation chamber operates at +0.5 °C than the lower plate, heated optic system
Software
Multi-user reader control (SMART Control and Voyager) and data analysis software (MARS).
FDA 21 CFR Part 11 compliance available with SMART Control and MARS.
Integrated fluorophore library.
Dimensions
Width: 35 cm, depth: 52 cm, height: 36 cm; weight: 27 kg
Optical Filters
Excitation and emission slides for up to 4 filters each for monochoromator units (VANTAstar), and for up to 5 filters each for filter-only units (VANTAstar F)
Optical Path Guides
Top and bottom: free-air optical light path guided by motor-driven mirrors and dichroics
Z-Adjustment
Automatic focal height adjustment (0.1 mm resolution)
Reagent Injection
Up to 2 reagent injectors
Individual injection volumes for each well: 3 to 500 μL (optionally up to 1 mL)
Variable injection speed up to 420 μL/s
Reagent back flushing
Heater and stirrer plate
Dimensions: width: 13 cm, depth: 31 cm, height: 26 cm; weight: 6 kg
Power Requirements
- External power supply
- Input Voltage: 100 - 240 V AC, 50 - 60 Hz, auto ranging.
- Input current ≤ 2.0 A.
- Output Voltage: 24 V DC / 6.25 A
Power Consumption
- Standby ≤ 0.15 W
- Idle mode 10 W
- Normal operating conditions 30 W
- Maximum 150 W
Optional Accessories
LVis Plate
Sample capacity: sixteen separate microdrop wells for 2 µL samples; one standard cuvette position for up to 1 mL samples
Quality Control Internal Standards (optional): four NIST traceable optical density filters (approximate values of 0.1, 0.3, 0.6 and 1.0 OD); one holmium oxide filter for wavelength accuracy
Dimensions: conforms to SBS standards for microplates
THERMOstar
Microplate incubator and shaker
Atmospheric Control Unit (ACU)
Actively regulates O2 and CO2 - 1-20%
Optical Filters
Excitation and emission filters
Upgrades
Upgrades to include options such as additional detection modes, reagent injectors, extended temperature control, etc. are available
Please contact your local representative for more information
*
LOD = 3 x SD (20 blanks) / slope (6 pt std curve)
96 = 96-well microplates
384sv = 384-well small volume microplates
384g = 384-well glass bottom microplates